The son of Renata Brillantini and Alvaro Pieranunzi, Enrico Pieranunzi was encouraged to study music at a young age. His father was a jazz guitarist. He studied classical music until 1973 when he became a Professor of Music, and remained in the post for two years. In 1975 he left his teaching practice and played in trios and small ensembles. He has recorded over 60 albums and has also been active as a session musician.